The international meeting on Epigenetic Penetrance of Reproductive Technologies was held at University of Teramo, Italy, from the 9th to the 10th of June 2016. The meeting was organised within the project of Horizon 2020 and it explored epigenetic studies in the context of reproductive technologies. A panel of distinguished international speakers addressed the impact of epigenetic modifications in assisted reproductive technologies on laboratory animals, livestock and humans. The meeting saw the participation of Prof Cesare Galli from Avantea, who chaired the first session of the conference.